Coenzyme Q-10 (Co Q-10) is a key antioxidant that has a big job: supporting you as you age gracefully.

Coenzyme Q-10 (Co Q-10) is a naturally occuring, fat soluble antioxidant that has a big job: supporting you as you age gracefully.  Free radicals can cause oxidative stress which may damage cells which is what makes Co Q-10 an important compound in your body. It is essential to the production of energy by almost every cell and functions as an antioxidant to fight free radicals.  Free radicals can cause oxidative stress which may damage cells. 
Co Q-10 contributes to cardiovascular wellness and energy production within your heart. If you're looking to support a healthy heart and blood-pressure levels that are already within a normal range, Co Q-10 does just that. It also promotes oral and gum health—which is also good for the heart.
Co Q-10 levels within cells may decline with age. They may also be reduced in those who take statin medications, which are often prescribed for high cholesterol. Q-SORB™ Co Q-10 can help replenish what statin medications deplete.

Note: Co Q-10 is not intended to serve as a replacement for statin therapy, nor should you discontinue taking any prescribed medications while supplementing with Co Q-10.  

Overview Information

Coenzyme Q10 is a vitamin-like substance found throughout the body, but especially in the heart, liver, kidney, and pancreas. It is eaten in small amounts in meats and seafood. Coenzyme Q10 can also be made in a laboratory.

Coenzyme Q10 is most commonly used for conditions that affect the heart such as heart failure and fluid build up in the body (congestive heart failure or CHF), chest pain (angina), and high blood pressure. It is also used for preventing migraine headache, Parkinson disease, and many other conditions.

Coenzyme Q10 was first identified in 1957. The "Q10" refers to the chemical make-up of the substance.

How does it work?

Coenzyme Q10 is an important vitamin-like substance required for the proper function of many organs and chemical reactions in the body. It helps provide energy to cells. Coenzyme Q10 also seems to have antioxidant activity. People with certain diseases, such as heart failure, high blood pressure, gum disease, Parkinson's disease, blood infections, certain diseases of the muscles, and HIV infection, might have lower levels of coenzyme Q10.

Uses & Effectiveness

- Coenzyme Q10 deficiency: Taking coenzyme Q10 by mouth seems to improve symptoms of coenzyme Q10 deficiency. This is a very rare condition. The symptoms include      weakness, fatigue, and seizures.

- A group of disorders that most often cause muscle weakness (mitochondrial myopathies): Taking coenzyme Q10 by mouth seems to reduce symptoms of mitochondrial      myopathies. However, improvement in symptoms is slow. Some people have to take coenzyme Q10 for 6 months to get the most benefit.

- Heart failure and fluid build up in the body (congestive heart failure or CHF): Early research found that heart failure might be linked with low coenzyme Q10 levels. Some    research shows that taking coenzyme Q10 might help reduce some symptoms of heart failure. Coenzyme Q10 might also reduce the chances of death or hospitalization related to    heart failure.

- Nerve pain in people with diabetes (diabetic neuropathy): Research shows that taking coenzyme Q10 improves nerve damage and nerve pain in people with nerve damage    caused by diabetes.

- Fibromyalgia: Some research shows that taking coenzyme Q10 by mouth reduces pain, tenderness, fatigue, and sleep issues in people with fibromyalgia.

- HIV/AIDS: Taking coenzyme Q10 by mouth seems to improve immune function in people with HIV/AIDS.

- Tissue damage caused when there is limited blood flow and then blood flow is restored (ischemia-reperfusion injury): Reduced blood supply during heart or blood vessel         surgery can deprive tissue of oxygen. When blood supply returns to this tissue, the tissue can become damaged. There is some evidence that taking coenzyme Q10 by mouth for at     least one week before heart bypass surgery or blood vessel surgery might help to reduce tissue damage.

- Migraine: Taking coenzyme Q10 by mouth seems to help prevent migraine. Research shows it can decrease the frequency of these headaches by about 30% and the number of    days with headache-related nausea by about 45% in adults. More than half of patients taking coenzyme Q10 experience a 50% decrease in the number of headache days per month.    Taking coenzyme Q10 also appears to reduce migraine frequency in children who have low levels of coenzyme Q10. It can take up to 3 months to see any benefit.

- Multiple sclerosis (MS): Taking coenzyme Q10 by mouth seems to reduce tiredness and low mood in people with MS.

- Heart attack: When started within 72 hours of a heart attack and taken for one year, coenzyme Q10 appears to lower the risk of heart-related events, including another heart attack.

- A disease that causes curved, painful erections (Peyronie disease): Research shows that taking coenzyme Q10 improves erectile function in men with painful erections.

-  Muscles pain due to statins used: Q10 can also reduced pain in those taking statin drugs, often prescribed for high cholesterol. Q-SORB ™ Co Q-10 can help restore statin          damage.

Side Effects & Safety

When taken by mouth: Coenzyme Q10 is LIKELY SAFE for most adults. While most people tolerate coenzyme Q10 well, it can cause some mild side effects including stomach upset, loss of appetite, nausea, vomiting, and diarrhea. It can cause allergic skin rashes in some people. It also might lower blood pressure, so check your blood pressure carefully if you have very low blood pressure. Dividing the total daily dose by taking smaller amounts two or three times daily instead of a large amount all at once can help reduce side effects.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Coenzyme Q10 is POSSIBLY SAFE when taken by mouth appropriately during pregnancy. Coenzyme Q10 has been used safely when taken twice daily starting at 20 weeks until delivery. Not enough is known about the use of coenzyme Q10 during breast-feeding. Stay on the safe side and avoid use.

Children: Coenzyme Q10 is POSSIBLY SAFE for children when taken by mouth. However, coenzyme Q10 should not be used in children without medical supervision.

Chemotherapy: People undergoing chemotherapy with a class of drugs called alkylating agents should use coenzyme Q10 with caution. There is some concern that coenzyme Q10 might lower the effectiveness of these drugs. Some alkylating agents include busulfan, carboplatin, cisplatin, cyclophosphamide (Cytoxan), dacarbazine, thiotepa, and many others.

High blood pressure or low blood pressure: Coenzyme Q10 might lower blood pressure. It can increase the effects of medications used to lower blood pressure. Discuss your use of coenzyme Q10 with your healthcare provider if you have blood pressure problems.

Smoking: Cigarette smoking depletes the amount of coenzyme Q10 stored by the body.

Surgery: Coenzyme Q10 might interfere with blood pressure control during and after surgery. Stop using coenzyme Q10 at least two weeks before a scheduled surgery.

Interactions

Be cautious with this combination:

Medications for cancer (Chemotherapy) interacts with COENZYME Q10

Coenzyme Q-10 is an antioxidant. There is some concern that antioxidants might decrease the effectiveness of some medications used for cancers. But it is too soon to know if the interaction occurs.

Medications for high blood pressure (Antihypertensive drugs) interacts with COENZYME Q10

Coenzyme Q-10 seems to decrease blood pressure. Taking coenzyme Q-10 along with medications for high blood pressure might cause your blood pressure to go too low. Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.

Warfarin (Coumadin) interacts with COENZYME Q10

Warfarin (Coumadin) is used to slow blood clotting. Coenzyme Q-10 might help the blood clot. By helping the blood clot, coenzyme Q-10 might decrease the effectiveness of warfarin (Coumadin). Decreasing the effectiveness of warfarin (Coumadin) might increase the risk of clotting. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.

Dosing

The following doses have been studied in scientific research:

ADULTS

BY MOUTH:

For coenzyme Q10 deficiency: 150-2400 mg per day.

For a group of disorders that most often cause muscle weakness (mitochondrial myopathies): 150-160 mg per day, or 2 mg/kg per day. In some cases, doses may be gradually increased to 3000 mg per day.

For heart failure and fluid build up in the body (congestive heart failure or CHF): 30 mg once daily, or up to 300 mg per day divided into two or three doses for up to 2 years. Also, 2 mg/kg daily for up to one year has been used.

For nerve pain in people with diabetes (diabetic neuropathy): 400 mg per day for 12 weeks.

For fibromyalgia: 300 mg daily for about 6 weeks or 200 mg twice daily for 3 months has been used. A combination of 200 mg of coenzyme Q10 (Bio-Quinon Q10, Pharma Nord) plus 200 mg of ginkgo (Bio-Biloba, Pharma Nord) per day for 12 weeks.

For HIV/AIDS: 100-200 mg per day for over 4 years.

For tissue damage caused when there is limited blood flow and then blood flow is restored (ischemia-reperfusion injury): 150-300 mg per day in up to three divided doses for 1-2 weeks before surgery.

For preventing migraine: 100 mg three times per day, 150 mg once per day, or 100mg once per day for 3 months. A dose of 1-3 mg/kg per day for 3 months has also been used.

For multiple sclerosis (MS): 500 mg twice daily for 3 months.

For heart attack: 120 mg per day in two divided doses for up to one year. A combination of 100 mg of coenzyme Q10 (Bio-Quinon, Pharma Nord) and 100 mcg of selenium (Bio-Selenium, Pharma Nord) per day for up to one year has also been used.

For Peyronie disease: 300 mg per day for 6 months

For muscles pain due to statin use: Minimum 200mg per day. 

CHILDREN

BY MOUTH:

For coenzyme Q10 deficiency: 60-250 mg per day in up to three divided doses.

For preventing migraine: 1-3 mg/kg daily for 3 months has been used in patients aged 3-18 years.

For a group of inherited disorders that cause muscle weakness and muscle loss (muscular dystrophy): 100 mg daily for 3 months in children aged 8-15 years.